N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

Base Information

Chemical Name:N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate
CAS No.:1268168-23-5
Molecular Formula:C₂₆H₃₁ClN₄O*H₂O₄S
Molecular Weight:549.091
Hs Code.:

Synonyms:N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

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Chemical Property of N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

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Technology Process of N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

There total 5 articles about N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 667925-61-3
N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo-[ 1,5-a]pyrimidine-3-carboxamide

: 1268168-23-5
N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

Guidance literature:: With sulfuric acid; In diethyl ether; at 20 ℃;
DOI:10.1021/jm101452x

Reference yield:

: 1260243-53-5
ethyl 7,7-dimethyl-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate

: 1268168-23-5
N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2.1: potassium hydroxide / ethanol; water / 14 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 80 °C

4.1: sulfuric acid / diethyl ether / 20 °C

With sodium tetrahydroborate; sulfuric acid; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm101452x

Reference yield:

: 667921-18-8
7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1268168-23-5
N-[1-(4-chlorophenyl)-1-ethylpropyl]-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropy-razolo[1,5-a]pyrimidine-3-carboxamide sulfate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 80 °C

2.1: sulfuric acid / diethyl ether / 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; HATU; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm101452x