9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

Base Information

• Chemical Name: 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate
• CAS No.: 777864-73-0
• Molecular Formula: C₂₇H₂₅NO₈S
• Molecular Weight: 523.563
• Mol file: 777864-73-0.mol

Synonyms:9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

Chemical Property of 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

There total 5 articles about 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoic acid (777864-71-8) + 2-hydroxy thioxanthone (31696-67-0) → 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate (777864-73-0)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1002/hlca.200590067

Reference yield:

tert-butyl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate (777864-70-7) → 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate (777864-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaH / dimethylformamide / 1 h / 20 °C

2: 64 percent / N,N-dimethylpyridin-4-amine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 24 h / 20 °C

With dmap; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.200590067

Reference yield:

4-Ethyl-3-nitrobenzoic acid (103440-95-5) → 9-oxo-9H-thioxanthen-2-yl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate (777864-73-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / N,N-dicyclohexylcarbodiimide; N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 3 h / 20 °C

2: 100 percent / t-BuOK / dimethylsulfoxide / 1 h / 20 °C

3: 85 percent / Et(i-Pr)2N / CH₂Cl₂ / 21 h / 20 °C

4: 94 percent / NaH / dimethylformamide / 1 h / 20 °C

5: 64 percent / N,N-dimethylpyridin-4-amine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 24 h / 20 °C

With dmap; potassium tert-butylate; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200590067

upstream raw materials:

4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoic acid

2-hydroxy thioxanthone

tert-butyl 4-{2-[(2-methoxyethoxy)methoxy]-1-methylethyl}-3-nitrobenzoate

4-Ethyl-3-nitrobenzoic acid

Downstream raw materials:

5'-O-{[2-(2-nitro-4-{[(9-oxo-9H-thioxanthen-2-yl)oxy]carbonyl}phenyl)propoxy]carbonyl}thymidine

9-oxo-9H-thioxanthen-2-yl 4-(2-hydroxy-1-methylethyl)-3-nitrobenzoate