(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

Base Information

Chemical Name:(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone
CAS No.:130675-59-1
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

Synonyms:(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

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Technology Process of (3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

There total 10 articles about (3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 130675-58-0
(3S,4R)-1-benzyl-3-(pyrrolidine-2,5-dion-1-yl)-4-styryl-2-azetidinone

: 130675-59-1
(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

Guidance literature:: With sodium methylate; In methanol; for 0.166667h; Ambient temperature;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-41-1
(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

: 130675-59-1
(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

2: TEA / CH₂Cl₂ / 0.5 h / 0 °C

3: 66.4 percent / TEA / CH₂Cl₂ / 15 h / 0 °C

4: 78 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

5: 80 percent / Jones reagent / acetone / 2 h / Ambient temperature

6: 46 percent / Pb(OAc)4, KOAc / dimethylformamide / 3 h / Ambient temperature

7: 61 percent / NaOMe / methanol / 0.17 h / Ambient temperature

With lead(IV) acetate; hydrogenchloride; jones reagent; TEA; hydrogen; sodium methylate; potassium acetate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.38.1601

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 130675-59-1
(3S,4R)-1-benzyl-3-<(3-methoxycarbonyl)propionamido>-4-styryl-2-azetidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / molecular sieves 4 A / benzene / 2 h / Ambient temperature

2: 66.4 percent / TEA / CH₂Cl₂ / 15 h / 0 °C

3: 78 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

4: 80 percent / Jones reagent / acetone / 2 h / Ambient temperature

5: 46 percent / Pb(OAc)4, KOAc / dimethylformamide / 3 h / Ambient temperature

6: 61 percent / NaOMe / methanol / 0.17 h / Ambient temperature

With lead(IV) acetate; hydrogenchloride; jones reagent; 4 A molecular sieve; TEA; sodium methylate; potassium acetate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1248/cpb.38.1601