4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

Base Information

Chemical Name:4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one
CAS No.:1644191-48-9
Molecular Formula:C₂₁H₂₇ClO₂Si₂
Molecular Weight:403.068
Hs Code.:

Synonyms:4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

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Chemical Property of 4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

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Technology Process of 4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

There total 2 articles about 4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 29955-12-2
bis(trimethylsilyl)methyl bromide

: 1644191-45-6
4-bromo-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

: 1644191-48-9
4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

Guidance literature:: bis(trimethylsilyl)methyl bromide; With chloro-trimethyl-silane; magnesium; lithium chloride; In tetrahydrofuran; ethylene dibromide; at 0 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

4-bromo-3-(4-chlorophenyl)isobenzofuran-1(3H)-one; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; toluene; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201402531

Reference yield:

: 69038-74-0
tert-butyl 3-bromobenzoate

: 104-88-1
4-chlorobenzaldehyde

: 1644191-48-9
4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 0.75 h / 0 °C / Schlenk technique; Inert atmosphere

1.2: -20 °C / Schlenk technique; Inert atmosphere

2.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

2.2: 12 h / 80 °C / Schlenk technique; Inert atmosphere

With chloro-trimethyl-silane; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; magnesium; lithium chloride; In tetrahydrofuran; ethylene dibromide; 2.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531