Technology Process of 4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one
There total 2 articles about 4-(bis(trimethylsilyl)methyl)-3-(4-chlorophenyl)isobenzofuran-1(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
bis(trimethylsilyl)methyl bromide;
With
chloro-trimethyl-silane; magnesium; lithium chloride;
In
tetrahydrofuran; ethylene dibromide;
at 0 ℃;
for 0.5h;
Schlenk technique;
Inert atmosphere;
4-bromo-3-(4-chlorophenyl)isobenzofuran-1(3H)-one;
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate;
In
tetrahydrofuran; toluene;
at 80 ℃;
for 12h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/chem.201402531
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 0.75 h / 0 °C / Schlenk technique; Inert atmosphere
1.2: -20 °C / Schlenk technique; Inert atmosphere
2.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere
2.2: 12 h / 80 °C / Schlenk technique; Inert atmosphere
With
chloro-trimethyl-silane; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; magnesium; lithium chloride;
In
tetrahydrofuran; ethylene dibromide;
2.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531
