3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1613332-90-3
Molecular Formula:C₂₃H₁₉Cl₂N₅
Molecular Weight:436.343
Hs Code.:

Synonyms:3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

There total 10 articles about 3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1613333-43-9
4-(4-(3-((2,5-dichlorophenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester

: 1613332-90-3
3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃;

Reference yield:

: 1562305-10-5
4-(4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1613332-90-3
3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide / acetone / 2 h / 20 °C

2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 16 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

4: potassium hydroxide; methanol / 2 h / 20 °C

5: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

6: hydrogenchloride / dichloromethane; ethyl acetate / 20 °C

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; potassium hydroxide; sodium hydroxide; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 877399-74-1
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1613332-90-3
3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux

2: N-iodo-succinimide / acetone / 2 h / 20 °C

3: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 16 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

5: potassium hydroxide; methanol / 2 h / 20 °C

6: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h / 75 °C / Inert atmosphere

7: hydrogenchloride / dichloromethane; ethyl acetate / 20 °C

With hydrogenchloride; methanol; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; triethylamine; potassium hydroxide; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;