Z-N-ME-DL-ALA-OH DCHA

Base Information

• Chemical Name: Z-N-ME-DL-ALA-OH DCHA
• CAS No.: 91738-83-9
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 91738-83-9.mol

Synonyms:Alanine,N-carboxy-N-methyl-, N-benzyl ester (7CI); DL-Alanine,N-methyl-N-[(phenylmethoxy)carbonyl]-; N-(Benzyloxycarbonyl)-N-methyl-DL-alanine;N-Methyl-N-[(phenylmethoxy)carbonyl]alanine

Chemical Property of Z-N-ME-DL-ALA-OH DCHA

Chemical Property:

• PSA: 78.87000
• LogP: 5.36040
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyloxycarbonyl-N-methyl-DL-alanine dicyclohexylammonium salt, 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-N-ME-DL-ALA-OH DCHA

There total 1 articles about Z-N-ME-DL-ALA-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylalanine (600-21-5) + benzyl chloroformate (501-53-1,94274-21-2) → N-((benzyloxy)carbonyl)-N-methyl-alanine (91738-83-9)

Guidance literature:

With sodium hydroxide;

Reference yield: 96.0%

N-((benzyloxy)carbonyl)-N-methyl-alanine (91738-83-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → benzyl 2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl(methyl)carbamate (596119-91-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 72.0%

N-((benzyloxy)carbonyl)-N-methyl-alanine (91738-83-9) + (8S) 5-(tert-butyloxycarbonyl)amino-6-oxodehydropyrazolo[1,2-a][1,2,5]triazaoctyl-8-carboxylic acid methyl ester → (8S)-3-(2-(benzyloxycarbonyl)methylamino)propionyl-5-(tert-butyloxycarbonyl)amino-6-oxodehydropyrazolo[1,2-a][1,2,5]triazaoctyl-8-carboxylic acid methyl ester

Guidance literature:

N-((benzyloxy)carbonyl)-N-methyl-alanine; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 1h;

(8S) 5-(tert-butyloxycarbonyl)amino-6-oxodehydropyrazolo[1,2-a][1,2,5]triazaoctyl-8-carboxylic acid methyl ester; In dichloromethane; at 20 ℃; for 6h;

upstream raw materials:

N-methylalanine

benzyl chloroformate

Downstream raw materials:

N-Z-N-Methyl-DL-alanin-cyanmethylester

benzyl 2-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-1-methyl-2-oxoethyl(methyl)carbamate