Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

Base Information

• Chemical Name: Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate
• CAS No.: 115499-21-3
• Molecular Formula: C₃₀H₄₀N₆O₈
• Molecular Weight: 612.683
• Mol file: 115499-21-3.mol

Synonyms:Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

Chemical Property of Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

There total 4 articles about Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Diethyl N-pyrimidin-6-yl>methyl>-N10-formyl-4-aminobenzoyl>glutamate (115499-18-8) → Diethyl N-pyrimidin-6-yl>methyl>-N10-formyl-4-aminobenzoyl>glutamate (115499-21-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 25 ℃; for 3h; under 2585.7 Torr;

DOI:10.1021/jm00127a019

Reference yield:

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) → Diethyl N-pyrimidin-6-yl>methyl>-N10-formyl-4-aminobenzoyl>glutamate (115499-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2) borane-triethylamine complex / 1) glacial acetic acid, 25 deg C, 14 h, 2) 25 deg C, 2 h

2: acetic anhydride / 1.5 h / 25 °C

3: 83 percent / H₂ / PtO₂ / acetic acid / 3 h / 25 °C / 2585.7 Torr

With triethylamine-borane; hydrogen; platinum(IV) oxide; In acetic anhydride; acetic acid;

DOI:10.1021/jm00127a019

Reference yield:

2-pivaloyl-6-formyl-5-deazapterin (120040-44-0) → Diethyl N-pyrimidin-6-yl>methyl>-N10-formyl-4-aminobenzoyl>glutamate (115499-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 2) borane-triethylamine complex / 1) glacial acetic acid, 25 deg C, 14 h, 2) 25 deg C, 2 h

2: acetic anhydride / 1.5 h / 25 °C

3: 83 percent / H₂ / PtO₂ / acetic acid / 3 h / 25 °C / 2585.7 Torr

With triethylamine-borane; hydrogen; platinum(IV) oxide; In acetic anhydride; acetic acid;

DOI:10.1021/jm00127a019

upstream raw materials:

Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

diethyl N-(p-aminobenzoyl)-L-glutamate

2-pivaloyl-6-formyl-5-deazapterin

Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate

Downstream raw materials:

N-pyrimidin-6-yl)methyl>-4-aminobenzoyl>glutamic Acid