tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate
CAS No.:1176327-18-6
Molecular Formula:C₂₀H₂₈BrNO₄
Molecular Weight:426.351
Hs Code.:

Synonyms:tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1176327-17-5
[4-bromo-3-(2-methoxyethoxy)benzyl](triphenyl)phosphonium bromide

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1176327-18-6
tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; In isopropyl alcohol; for 11.5h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 1176327-15-3
4-bromo-3-(2-methoxyethoxy)benzoic acid

: 1176327-18-6
tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3.5 h / 25 °C

1.2: 0.33 h / 20 °C

2.1: hydrogen bromide / toluene; water / 2 h / 65 - 70 °C

3.1: toluene / 3.5 h / Reflux

4.1: potassium carbonate / isopropyl alcohol / Reflux

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen bromide; potassium carbonate; In tetrahydrofuran; water; isopropyl alcohol; toluene;

Reference yield:

: 1-bromo-4-(bromomethyl)-2-(2-methoxyethoxy)benzene

: 1176327-18-6
tert-butyl 4-(4-bromo-3-(2-methoxyethoxy)benzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 3.5 h / Reflux

2: potassium carbonate / isopropyl alcohol / Reflux

With potassium carbonate; In isopropyl alcohol; toluene;