(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Base Information

Chemical Name:(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid
CAS No.:1400703-82-3
Molecular Formula:C₂₅H₂₈N₄O₅S
Molecular Weight:496.587
Hs Code.:

Synonyms:(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

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Chemical Property of (S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

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Technology Process of (S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

There total 13 articles about (S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400706-23-1
C₂₆H₃₀N₄O₅S

: 1400703-82-3
(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: C₂₆H₃₀N₄O₅S; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

With potassium hydrogensulfate; In 1,4-dioxane; pH=3;

Reference yield:

: 626-02-8
3-Iodophenol

: 1400703-82-3
(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: potassium carbonate; tetrabutyl-ammonium chloride / palladium diacetate / N,N-dimethyl-formamide / 1 h / 70 °C

1.2: 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2585.81 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

4.1: Lawessons reagent / xylenes / 3 h / Reflux

5.1: ammonia; ammonium chloride / methanol / 0.67 h / Reflux

6.1: pyridine; acetic acid / methanol / 26 h / Reflux

7.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / Reflux

7.2: pH 3 / buffer

8.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane / 1 h

10.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

11.1: phenylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.67 h / 20 °C

11.2: pH 3 / Acidic conditions; buffer

12.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C

12.2: pH 3

With Lawessons reagent; pyridine; hydrogenchloride; lithium hydroxide monohydrate; phenylsilane; tetrabutyl-ammonium chloride; ammonia; water; hydrogen; potassium carbonate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; xylenes;

Reference yield:

: 143536-52-1
ethyl 5-(3-hydroxyphenyl)pentanoate

: 1400703-82-3
(S)-2-({2-[4-(3-hydroxy-phenyl)butyl]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C

2.1: Lawessons reagent / xylenes / 3 h / Reflux

3.1: ammonia; ammonium chloride / methanol / 0.67 h / Reflux

4.1: pyridine; acetic acid / methanol / 26 h / Reflux

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / Reflux

5.2: pH 3 / buffer

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 1 h

8.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

9.1: phenylsilane / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane / 0.67 h / 20 °C

9.2: pH 3 / Acidic conditions; buffer

10.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C

10.2: pH 3

With Lawessons reagent; pyridine; hydrogenchloride; lithium hydroxide monohydrate; phenylsilane; ammonia; water; potassium carbonate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; xylenes;