O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester

Base Information

• Chemical Name: O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester
• CAS No.: 727376-65-0
• Molecular Formula: C₃₀H₄₂N₄O₁₃
• Molecular Weight: 666.682

Synonyms:O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester

Chemical Property of O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester

There total 3 articles about O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[O-ethyl-N-(O-ethyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-α-glutamyl]-L-glutamic acid diethyl ester (3062-24-6) → O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester (727376-65-0)

Guidance literature:

With palladium on activated charcoal; ethanol; at 50 ℃; Hydrogenation_.Behandlung des Reaktionsprodukts mit wss. Natriumhydrogencarbonat-Loesung und mit 4-Nitro-benzoesaeure-chlorid in Chloroform oder Aether;

DOI:10.1021/ja01175a012

Reference yield:

→ O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester (727376-65-0)

Guidance literature:

With hydrogenchloride; ethanol; anschl. mit Triaethylamin in Aethylacetat und mit 4-Nitro-benzoylchlorid;

DOI:10.1021/ja01157a021

Reference yield:

N-[O5-ethyl-N-(N-benzyloxycarbonyl-α-L-glutamyl)-α-L-glutamyl]-L-glutamic acid diethyl ester (888936-27-4) → O-ethyl-N-(4-nitro-benzoyl)-L-α-glutamyl->O-ethyl-L-α-glutamyl->L-glutamic acid diethyl ester (727376-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid-monohydrate / 55 - 60 °C

2: ethanol; palladium/charcoal / 50 °C / Hydrogenation_.Behandlung des Reaktionsprodukts mit wss. Natriumhydrogencarbonat-Loesung und mit 4-Nitro-benzoesaeure-chlorid in Chloroform oder Aether

With palladium on activated charcoal; ethanol; toluene-4-sulfonic acid;

DOI:10.1021/ja01175a012

upstream raw materials:

N-[O-ethyl-N-(O-ethyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-α-glutamyl]-L-glutamic acid diethyl ester

N-[O⁵-ethyl-N-(N-benzyloxycarbonyl-α-L-glutamyl)-α-L-glutamyl]-L-glutamic acid diethyl ester

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