2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine

Base Information

• Chemical Name: 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine
• CAS No.: 153765-18-5
• Molecular Formula: C₃₇H₄₁N₅O₇S
• Molecular Weight: 699.828
• Mol file: 153765-18-5.mol

Synonyms:2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine

Chemical Property of 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine

There total 4 articles about 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N²-isobutyrylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.3%

2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-3'-O-(diphenyl-tert-butylsilyl)-N2-isobutyrylguanosine (153765-17-4) → 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N2-isobutyrylguanosine (153765-18-5)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1016/S0040-4039(00)73706-3

Reference yield:

2',5'-dideoxy-5'-iodo-3'-O-(diphenyl-tert-butylsilyl)-N2-isobutyrylguanosine → 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N2-isobutyrylguanosine (153765-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.5 percent / dioxane / 3.5 h / Ambient temperature

2: 84.75 percent / pyridine / Ambient temperature

3: 79.3 percent / TBAF / tetrahydrofuran / 2 h / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; pyridine;

DOI:10.1080/15257779408013239

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-N2-isobutyrylguanosine (153765-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.75 percent / pyridine / Ambient temperature

2: 79.3 percent / TBAF / tetrahydrofuran / 2 h / Ambient temperature

With tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine;

DOI:10.1080/15257779408013239

upstream raw materials:

2',5'-dideoxy-5'-(2-O-4,4'-dimethoxytritylthio)-3'-O-(diphenyl-tert-butylsilyl)-N²-isobutyrylguanosine

4,4'-dimethoxytrityl chloride

2',5'-dideoxy-5'-(2-hydroxyethylthio)-3'-O-(diphenyl-tert-butylsilyl)-N²-isobutyrylguanosine