(1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate

Base Information

• Chemical Name: (1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate
• CAS No.: 1253968-83-0
• Molecular Formula: C₁₁H₁₄ClNO₂
• Molecular Weight: 227.691
• Mol file: 1253968-83-0.mol

Synonyms:(1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate

Chemical Property of (1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate

There total 1 articles about (1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(1S,2S,6R,7R,9R)-6-methyl-10-12-dioxatricyclo-[7.2.1.0(2,7)]dodec-4-en-8-one-syn-oxime → (1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate (1253968-83-0)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1134/S1070428010080063

Reference yield: 99.0%

(1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate (1253968-83-0) → (1R,2R,6S)-6-[(1S)-2-chloro-1-hydroxyethyl]-2-methylcyclohex-3-ene-1-carbonitrile (1253968-84-1)

Guidance literature:

With water; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1134/S1070428013070051

Reference yield: 94.0%

(1S)-2-chloro-1-[(1S,5R,6R)-6-cyano-5-methyl-cyclohex-3-en-1-yl]ethyl formate (1253968-83-0) → (1R,2R,6S)-6-[(1R)-1-hydroxyethyl]-2-methylcyclohex-3-ene-1-carbonitrile (1253968-88-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1134/S1070428013070051

Downstream raw materials:

(1R,2R,6S)-6-[(1S)-2-chloro-1-hydroxyethyl]-2-methylcyclohex-3-ene-1-carbonitrile

(1R,2R,6S)-6-[(1S)-2-ethoxy-1-hydroxyethyl]-2-methylcyclohex-3-ene-1carbonitrile

(1R,2R,6S)-6-[(1R)-1-hydroxyethyl]-2-methylcyclohex-3-ene-1-carbonitrile