2-amino-6-hydroxy-2-tetralincarboxylic acid

Base Information

Chemical Name:2-amino-6-hydroxy-2-tetralincarboxylic acid
CAS No.:84809-70-1
Molecular Formula:C₁₁H₁₃NO₃
Molecular Weight:207.229
Hs Code.:

Synonyms:2-amino-6-hydroxy-2-tetralincarboxylic acid

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Chemical Property of 2-amino-6-hydroxy-2-tetralincarboxylic acid

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Technology Process of 2-amino-6-hydroxy-2-tetralincarboxylic acid

There total 1 articles about 2-amino-6-hydroxy-2-tetralincarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 144646-02-6
3',4'-dihydro-6'-methoxyspiro-2,5-dione

: 84809-70-1
2-amino-6-hydroxy-2-tetralincarboxylic acid

Guidance literature:: With 48percent aq. HBr; for 48h; Heating;
DOI:10.1021/jm9911534

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 84809-70-1
2-amino-6-hydroxy-2-tetralincarboxylic acid

: 141824-13-7
N^α-Boc-DL-Hat-OH

: bis-tert-butoxycarbonyl-Hat

Guidance literature:: In 1,4-dioxane; water; at 20 ℃; for 96h; pH=10;
DOI:10.1021/jm9911534

Reference yield:

: 84809-70-1
2-amino-6-hydroxy-2-tetralincarboxylic acid

: 73301-07-2
[(2-amino-6-hydroxy-2-tetralinyl)carbonyl]glycylglycyl-L-phenylalanyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 2N aq. NaOH, CuSO₄, 3.) aq. HCl

2: 1.) 2 N aq. NaOH / 1.) heating, 2.) RT, 60 h

3: 89 percent / Et₃N, 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 56 h / Ambient temperature

4: 34 percent / H₂ / 5percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; copper(II) sulfate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00359a024