2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol

Base Information

• Chemical Name: 2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol
• CAS No.: 163061-18-5
• Molecular Formula: C₃₂H₃₄O₂Si
• Molecular Weight: 478.706
• Mol file: 163061-18-5.mol

Synonyms:2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol

Chemical Property of 2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol

There total 1 articles about 2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1,1,2-triphenyl-1,2-ethanediol (108998-83-0) + 1-chloro-2,5-dimethyl-1-phenyl-1-silacyclopentane → 2S-2-<(2R,5R-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol + 2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol (163061-18-5) + 2S-2-<(r-1,c-2,c-5-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol + 2S-2-<(r-1,t-2,t-5-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; Yield given. Yields of byproduct given; 1.) room temperature, 24 h, 2.) 60 deg C (bath temperature), 4 h;

DOI:10.1039/P19950000117

Reference yield: 96.0%

2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol (163061-18-5) → (S)-1,1,2-triphenyl-1,2-ethanediol (108998-83-0) + (2S,5S)-trans-2,5-dimethyl-1-phenyl-1-silacyclopentane (163061-10-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1039/P19950000117

Reference yield:

2S-2-<(2S,5S-2,5-dimethyl-1-phenyl-1-silacyclopentyl)oxy>-1,1,2-triphenylethanol (163061-18-5) → (2S,5S)-1-(9-anthrylmethoxy)-2,5-dimethyl-1-phenyl-1-silacyclopentane

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

2: CuCl₂ / acetonitrile / 1.) reflux, 1 h, 2.) room temperature, 1 h

3: imidazole, DMAP / dimethylformamide / 10 h / 40 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; copper dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/P19950000117

upstream raw materials:

(S)-1,1,2-triphenyl-1,2-ethanediol

Downstream raw materials:

(S)-1,1,2-triphenyl-1,2-ethanediol

(2S,5S)-trans-2,5-dimethyl-1-phenyl-1-silacyclopentane