Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI)

Base Information

• Chemical Name: Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI)
• CAS No.: 91622-91-2
• Molecular Formula: C10H11 N3 O
• Molecular Weight: 189.21384
• Mol file: 91622-91-2.mol

Synonyms:Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI)

Chemical Property of Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI)

Chemical Property:

• PSA: 45.23000
• LogP: 1.20550

Purity/Quality:

98%min ^*data from raw suppliers

6a,7,8,9-Tetrahydro-5H-pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI)

There total 4 articles about Pyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one, 6a,7,8,9-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3-nitropyridin-2-yl)proline → 6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one (91622-91-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 90 ℃; under 26252.6 Torr; Reagent/catalyst; Temperature; Pressure;

DOI:10.1002/jhet.4270

Reference yield: 69.0%

3-amino-2-bromopyridine (39856-58-1) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one (91622-91-2)

Guidance literature:

With copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 120 ℃; for 5h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.6b01350

Reference yield: 56.0%

N-(3-nitro-2-pyridinyl)pyrrolidine-2-carboxylic acid (36976-98-4) → 6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one (91622-91-2)

Guidance literature:

With iron; acetic acid; at 60 - 65 ℃; for 3h;

DOI:10.1021/jm00378a039

upstream raw materials:

N-(3-nitro-2-pyridinyl)pyrrolidine-2-carboxylic acid

2-Chloro-3-nitropyridine

3-amino-2-bromopyridine

rac-Pro-OH

Downstream raw materials:

5-<(2,6-dimethoxyphenyl)methyl>-6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one

6a,7,8,9-tetrahydro-5-(phenylmethyl)pyrido<3,2-a>pyrrolo<1,2-a>pyrazin-6(5H)-one

5-<3-(2,3-dimethylphenoxy)-2-hydroxypropyl>-6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one

5-<3-(2,3-dimethylphenoxy)-2-hydroxypropyl>-6a,7,8,9-tetrahydropyrido<3,2-e>pyrrolo<1,2-a>pyrazin-6(5H)-one