C₂₀H₂₁N₃O₄

Base Information

• Chemical Name: C₂₀H₂₁N₃O₄
• CAS No.: 1598418-78-0
• Molecular Formula: C₂₀H₂₁N₃O₄
• Molecular Weight: 367.404
• Mol file: 1598418-78-0.mol

Synonyms:C₂₀H₂₁N₃O₄

Chemical Property of C₂₀H₂₁N₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁N₃O₄

There total 6 articles about C₂₀H₂₁N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

C21H21N3O4 → C20H21N3O4 (1598418-78-0)

Guidance literature:

With potassium hexacyanoferrate(III); potassium hydroxide; In chloroform; water; at 0 ℃; Reagent/catalyst; Solvent;

DOI:10.1016/j.tet.2014.03.061

Reference yield:

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) → C20H21N3O4 (1598418-78-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: thionyl chloride / methanol / 2.5 h / 0 °C / Inert atmosphere; Reflux

3.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate / 2 h / 20 °C

5.1: boron tribromide / dichloromethane / 0 - 20 °C

6.1: hydrogenchloride; acetic acid / dimethyl sulfoxide / 20 °C

7.1: potassium hexacyanoferrate(III); potassium hydroxide / chloroform; water / 0 °C

With hydrogenchloride; thionyl chloride; boron tribromide; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hexacyanoferrate(III); potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; ethyl acetate; mineral oil;

DOI:10.1016/j.tet.2014.03.061

Reference yield:

D-N-Me-Tyr(OMe)-OMe hydrochloride (1449611-43-1) → C20H21N3O4 (1598418-78-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 2 h / 20 °C

3: boron tribromide / dichloromethane / 0 - 20 °C

4: hydrogenchloride; acetic acid / dimethyl sulfoxide / 20 °C

5: potassium hexacyanoferrate(III); potassium hydroxide / chloroform; water / 0 °C

With hydrogenchloride; boron tribromide; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hexacyanoferrate(III); potassium hydroxide; In dichloromethane; chloroform; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.tet.2014.03.061

upstream raw materials:

D-N-Me-Tyr(OMe)-OMe hydrochloride

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

N-Boc-N,O-dimethyl-D-tyrosine

C₂₈H₃₅N₃O₆