2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

Base Information

Chemical Name:2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester
CAS No.:1160001-17-1
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

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Chemical Property of 2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

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Technology Process of 2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

There total 4 articles about 2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1071475-13-2
([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanol)

: 920-46-7,26937-45-1
Methacryloyl chloride

: 1160001-17-1
2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;
DOI:10.1002/pola.27234

Reference yield:

: 100-79-8,36543-79-0
(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

: 1160001-17-1
2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran / 0 °C

2.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

2.2: 120 h / 75 °C

3.1: acetic acid; sodium cyanoborohydride / tetrahydrofuran; ethanol / 12 h / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

With 18-crown-6 ether; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/pola.27234

Reference yield:

: 23737-51-1,7305-59-1
solketal tosylate

: 1160001-17-1
2-methylacrylic acid 3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

1.2: 120 h / 75 °C

2.1: acetic acid; sodium cyanoborohydride / tetrahydrofuran; ethanol / 12 h / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

With 18-crown-6 ether; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/pola.27234