7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

Base Information

Chemical Name:7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide
CAS No.:205701-16-2
Molecular Formula:C₂₁H₁₉F₂N₃O₄
Molecular Weight:415.396
Hs Code.:

Synonyms:7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

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Chemical Property of 7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

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Technology Process of 7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

There total 6 articles about 7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 205700-49-8
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid [4-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-phenyl]-amide

: 205701-16-2
7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

Guidance literature:: 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydro-benzo[4,5]imidazo[1,2-a]pyridine-4-carboxylic acid [4-(tert-butyl-diphenyl-silanyloxy)-2-fluoro-phenyl]-amide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 205701-16-2
7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide

2: H₂ / 10 percent Pd/C / methanol; ethyl acetate / 2844.31 Torr

3: xylene / 140 °C

4: NaH; 15-crown-5 / dimethylformamide

5: nBu₄NF / tetrahydrofuran

With 1H-imidazole; 15-crown-5; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; xylene;
DOI:10.1016/S0960-894X(02)00463-8

Reference yield:

: 214145-04-7
tert-butyl-(3-fluoro-4-nitro-phenoxy)-diphenyl-silane

: 205701-16-2
7-Fluoro-1,2-dihydro-5-ethoxymethyl-3-oxo-N-(2-fluoro-4-hydroxyphenyl)pyrido[1,2-a]benzimidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd/C / methanol; ethyl acetate / 2844.31 Torr

2: xylene / 140 °C

3: NaH; 15-crown-5 / dimethylformamide

4: nBu₄NF / tetrahydrofuran

With 15-crown-5; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; xylene;
DOI:10.1016/S0960-894X(02)00463-8