4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide
• CAS No.: 1627947-11-8
• Molecular Formula: C₁₀H₁₂F₃NO₃S
• Molecular Weight: 283.271
• Mol file: 1627947-11-8.mol

Synonyms:4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide

There total 1 articles about 4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-amino-1,1,1-trifluoropropan-2-ol (431-38-9) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide (1627947-11-8)

Guidance literature:

With pyridine; for 4.5h; Reflux;

DOI:10.1002/chem.201304759

Reference yield:

4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide (1627947-11-8) → 2-(trifluoromethyl)-N-tosylaziridine (1226575-23-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/chem.201304759

Reference yield:

4-methyl-N-(3,3,3-trifluoro-2-hydroxypropyl)benzenesulfonamide (1627947-11-8) → 2-methoxymethyl-1-tosyl-2-(trifluoromethyl)pyrrolidine (1627947-37-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / 0.08 h / -100 °C / Inert atmosphere

2.2: 3 h / -100 - -40 °C / Inert atmosphere

3.1: 2 h / Reflux

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane;

DOI:10.1002/chem.201304759

upstream raw materials:

3-amino-1,1,1-trifluoropropan-2-ol

p-toluenesulfonyl chloride

Downstream raw materials:

2-methoxymethyl-1-tosyl-2-(trifluoromethyl)pyrrolidine

2-ethoxymethyl-1-tosyl-2-(trifluoromethyl)pyrrolidine

2-chloromethyl-1-tosyl-2-(trifluoromethyl)piperidine

2-isopropylaminomethyl-1-tosyl-2-(trifluoromethyl)piperidine