2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

Base Information

Chemical Name:2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone
CAS No.:1622219-83-3
Molecular Formula:C₁₆H₁₂F₄O₃
Molecular Weight:328.263
Hs Code.:

Synonyms:2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

Chemical Property:

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Technology Process of 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

There total 5 articles about 2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1622219-82-2
(4-(difluoromethoxy)-3-methylphenyl)(2-(3,5-difluorophenyl)-1,3-dithian-2-yl)methanol

: 1622219-83-3
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

Guidance literature:: With bis-[(trifluoroacetoxy)iodo]benzene; In water; acetonitrile; at 20 ℃; for 0.333333h;

Reference yield:

: 1622219-78-6
2-(3,5-difluorophenyl)-1,3-dithiane

: 1622219-83-3
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

1.2: 0.42 h / 20 °C

2.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 0.33 h / 20 °C

With n-butyllithium; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; water; acetonitrile;

Reference yield:

: 15174-69-3
4-hydroxy-3-methyl-benzaldehyde

: 1622219-83-3
2-(4-(difluoromethoxy)-3-methylphenyl)-1-(3,5-difluorophenyl)-2-hydroxyethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3.25 h / 95 °C

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -10 °C / Inert atmosphere

2.2: 0.42 h / 20 °C

3.1: bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 0.33 h / 20 °C

With n-butyllithium; potassium carbonate; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;