3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

Base Information

Chemical Name:3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene
CAS No.:773876-52-1
Molecular Formula:C₂₉H₃₉FN₂O₄
Molecular Weight:498.638
Hs Code.:

Synonyms:3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

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Chemical Property of 3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

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Technology Process of 3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

There total 1 articles about 3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 100-01-6,104810-17-5
4-nitro-aniline

: 649723-80-8
trans-3β-acetoxy-16,17-seco-pregna-5,17(20)-dien-16-al

: 773876-52-1
3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

: 773876-25-8
1',4',16,17-tetrahydro-3β-acetoxy-6'-nitro-4'-methyl-(16β,17α)-androsta-5,16-dieno[17,16-b]quinoline

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;
DOI:10.1016/j.steroids.2004.01.004

Reference yield: 89.0%

: 108-22-5
Isopropenyl acetate

: 773876-52-1
3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

: 3β-acetoxy-N-acetyl-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 1.5h;
DOI:10.1016/j.steroids.2004.01.004

Reference yield:

: 773876-52-1
3β-acetoxy-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

: 3β-hydroxy-N-acetyl-16β-[N-(4'-nitro)phenyl]amino-17aβ-fluoro-17α-methyl-D-homo-androsta-5-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / p-toluenesulfonic acid / benzene / 1.5 h

2: 88 percent / NaOMe / methanol

With sodium methylate; toluene-4-sulfonic acid; In methanol; benzene;
DOI:10.1016/j.steroids.2004.01.004