Technology Process of (S)-1-(2-(3-(4-fluorophenyl)propyl)hexyl)indoline
There total 5 articles about (S)-1-(2-(3-(4-fluorophenyl)propyl)hexyl)indoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
nickel(II) bromide 2-methoxyethyl ether complex; (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; potassium tert-butylate;
In
di-isopropyl ether; hexan-1-ol;
at 20 ℃;
for 40h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ja203560q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: di-isopropyl ether / 1 h / 60 °C
2: nickel(II) bromide diethylene glycol dimethyl ether; (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; potassium tert-butylate / di-isopropyl ether; hexan-1-ol / 40 h / 20 °C
With
nickel(II) bromide diethylene glycol dimethyl ether; (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; potassium tert-butylate;
In
di-isopropyl ether; hexan-1-ol;
2: Suzuki cross coupling;
DOI:10.1021/ja203560q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: borane-THF / tetrahydrofuran / 18 h / Reflux
2: nickel(II) bromide 2-methoxyethyl ether complex; (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; potassium tert-butylate / di-isopropyl ether; hexan-1-ol / 40 h / 20 °C
With
borane-THF; nickel(II) bromide 2-methoxyethyl ether complex; (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; potassium tert-butylate;
In
tetrahydrofuran; di-isopropyl ether; hexan-1-ol;
2: Suzuki cross coupling;
DOI:10.1021/ja203560q
