4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

Base Information

Chemical Name:4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran
CAS No.:139486-93-4
Molecular Formula:C₂₁H₂₂FNO₄S
Molecular Weight:403.474
Hs Code.:

Synonyms:4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

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Chemical Property of 4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

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Technology Process of 4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

There total 7 articles about 4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: bromomethyl-3-methyl-2,3-dihydrobenzothiazol-2-one

: 130723-09-0
4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran

: 139486-93-4
4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

Guidance literature:: With potassium carbonate; In diethyl ether; hexane; water; N,N-dimethyl-formamide;

Reference yield: 77.0%

: 139487-07-3
6-bromomethyl-3-methyl-2,3-dihydrobenzothiazol-2-one

: 130723-09-0
4-(5-fluoro-3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran

: 139486-93-4
4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00092a010

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 139486-93-4
4-[5-fluoro-3-(3-methyl-2-oxo-2,3-dihydrobenzothiazol-6-ylmethoxy)-phenyl]-4-methoxytetrahydropyran

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 1 h, 2.) THF, hexane, from -70 to 0 deg C, 3 h

2: 1.) NaH / 1.) DMF, 5 deg C, 1 h, 2.) DMF, from 5 deg C to RT, overnight

3: 95 percent / H₂ / 10percent Pd/C / ethanol / 2 h

4: 77 percent / K₂CO₃ / dimethylformamide / Ambient temperature

With n-butyllithium; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a010