3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Base Information

• Chemical Name: 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide
• CAS No.: 618428-58-3
• Molecular Formula: C₃₅H₄₇N₅O₆S
• Molecular Weight: 665.854
• Mol file: 618428-58-3.mol

Synonyms:3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Chemical Property of 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

There total 2 articles about 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-{3(S)-[N-(N-methyl-5-isoquinolinyloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide iodide → 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide (618428-58-3)

Guidance literature:

With sodium hydrogencarbonate; sodium thiosulfate; In water; for 3h;

DOI:10.1002/ardp.200390003

Reference yield:

(R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(S)-2-(5-isoquinolinyloxyacetyl)amino-3-methylbutanoyl]amino-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide (156880-90-9) → 3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide (618428-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88.5 percent / methanol / 2 h / 50 °C

2: 78 percent / NaHCO₃; Na₂S₂O₃ / H₂O / 3 h

With sodium hydrogencarbonate; sodium thiosulfate; In methanol; water;

DOI:10.1002/ardp.200390003

Reference yield:

3-{3(S)-[N-(N-methyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide (618428-58-3) → 3-{3(S)-[N-(N-methyl-5-isoquinolinyloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Guidance literature:

With silver nitrate; In methanol; Kinetics;

DOI:10.1002/ardp.200390003

upstream raw materials:

(R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(S)-2-(5-isoquinolinyloxyacetyl)amino-3-methylbutanoyl]amino-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide