6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Base Information

Chemical Name:6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one
CAS No.:1349820-97-8
Molecular Formula:C₂₉H₂₇F₄NO₃
Molecular Weight:513.532
Hs Code.:

Synonyms:6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Chemical Property of 6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

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Technology Process of 6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

There total 15 articles about 6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1349820-67-2
6-butyl-3-iodo-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 503309-11-3
2-fluoro-4-(trifluoromethyl)phenylboronic acid

: 1349820-97-8
6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Schlenk technique; Inert atmosphere;

Reference yield: 48.0%

: 1349820-59-2
6-chloro-3-ethyl-2-methyl-7-(2-morpholin-4-ylethoxy)-1H-quinolin-4-one

: 503309-11-3
2-fluoro-4-(trifluoromethyl)phenylboronic acid

: 1349820-97-8
6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;
DOI:10.1021/jm200718m

Reference yield:

: 1349821-29-9
N-[4-chloro-3-(2-morpholin-4-yl-ethoxy)phenyl]acetamide

: 1349820-97-8
6-butyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / ethanol; water / Reflux

2: acetic acid / benzene

3: diphenylether / Reflux

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic acid; potassium hydroxide; In diphenylether; ethanol; water; N,N-dimethyl-formamide; benzene; 2: Conrad-Limpach synthesis / 4: Suzuki coupling;
DOI:10.1021/jm200718m