(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

Base Information

Chemical Name:(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride
CAS No.:1311380-09-2
Molecular Formula:C₂₉H₂₄N₄O*ClH
Molecular Weight:480.997
Hs Code.:

Synonyms:(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

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Chemical Property of (4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

Chemical Property:

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Technology Process of (4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

There total 3 articles about (4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311380-49-0
tert-butyl (4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}benzyl)carbamate

: 1311380-09-2
(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 917363-91-8
[4-(5-chloro-3-phenyl-[1,6]naphthyridin-2-yl)-benzyl]-carbamic acid tert-butyl ester

: 1311380-09-2
(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 24 h / 75 °C

2.2: pH 4

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 60 °C / microwave irradiation

4.1: hydrogenchloride / dichloromethane; ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1238324-37-2
tert-butyl [4-(5-cyano-3-phenyl-1,6-naphthyridin-2-yl)benzyl]carbamate

: 1311380-09-2
(4-{5-[(benzylamino)carbonyl]-3-phenyl-1,6-naphthyridin-2-yl}phenyl)methanaminium chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 24 h / 75 °C

1.2: pH 4

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 60 °C / microwave irradiation

3.1: hydrogenchloride / dichloromethane; ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;