{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

Base Information

Chemical Name:{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile
CAS No.:1607590-75-9
Molecular Formula:C₂₀H₂₃N₅S
Molecular Weight:365.502
Hs Code.:

Synonyms:{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

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Chemical Property of {trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

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Technology Process of {trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

There total 13 articles about {trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1607590-73-7
[trans-4-(2-azetidin-3-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile

: 1607590-75-9
{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

Guidance literature:: formaldehyd; [trans-4-(2-azetidin-3-yl-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl)cyclohexyl]acetonitrile; In tetrahydrofuran; methanol; water; acetonitrile; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 1h;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607590-75-9
{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

5.2: 2 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: water; tetrahydrofuran; methanol; acetonitrile / 0.17 h / 20 °C

7.2: 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607590-75-9
{trans-4-[2-(1-methylazetidin-3-yl)-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl]cyclohexyl}acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 1 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

4.2: 2 h / Reflux

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: water; tetrahydrofuran; methanol; acetonitrile / 0.17 h / 20 °C

6.2: 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; acetonitrile;