(Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene

Base Information

• Chemical Name: (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene
• CAS No.: 187585-24-6
• Molecular Formula: C₈H₅ClFNO₂
• Molecular Weight: 201.585
• Mol file: 187585-24-6.mol

Synonyms:(Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene

Chemical Property of (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene

There total 3 articles about (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trans-1-(4-fluorophenyl)-2-nitro-ethene (706-08-1,5153-69-5) → (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene (187585-24-6)

Guidance literature:

With hydrogenchloride; sulfuryl dichloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1055/s-0040-1707396

Reference yield: 77.0%

bromonitromethane (563-70-2) + 4-fluorobenzaldehyde (459-57-4) → (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene (187585-24-6)

Guidance literature:

With potassium fluoride; N,N-dimethylammonium chloride; In xylene; for 3h; Heating;

DOI:10.1016/S0223-5234(97)84363-2

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (Z)-1-(2-chloro-2-nitrovinyl)-4-fluorobenzene (187585-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethylenediammonium bistrifluoroacetate / dimethyl sulfoxide / 17 h / 110 °C

2: sulfuryl dichloride; hydrogenchloride / dichloromethane; 1,4-dioxane / 48 h / 20 °C / Inert atmosphere

With hydrogenchloride; sulfuryl dichloride; ethylenediammonium bistrifluoroacetate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1055/s-0040-1707396

upstream raw materials:

bromonitromethane

4-fluorobenzaldehyde

trans-1-(4-fluorophenyl)-2-nitro-ethene

Downstream raw materials:

2-(4-Fluoro-phenyl)-3-nitro-chromen-4-one

3-amino-2-(4-fluorophenyl)-4H-1-benzopyran-4-one