2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

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Chemical Name:2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile
CAS No.:1422455-78-4
Molecular Formula:C₃₂H₄₁F₃N₁₀O₂Si
Molecular Weight:682.824
Hs Code.:

2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

Synonyms:2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

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Chemical Property of 2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

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Technology Process of 2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

There total 8 articles about 2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422455-70-6
[6-[(cis-4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}cyclohexyl)oxy]-2-(trifluoromethyl)pyrimidin-4-yl]methyl methanesulfonate

: 1422455-78-4
2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; water; at 25 ℃; for 16h;

Reference yield:

: 1422455-63-7
4-{[6-(hydroxymethyl)-2-(trifluoromethyl)pyrimidin-4-yl]oxy}cyclohexanone

: 1422455-78-4
2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

3: ammonium hydroxide / tetrahydrofuran; water / 16 h / 25 °C

With ammonium hydroxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1422455-61-5
[6-(1,4-dioxaspiro[4.5]dec-8-yloxy)-2-(trifluoromethyl)pyrimidin-4-yl]methanol

: 1422455-78-4
2-(1-((1s,4s)-4-(6-(aminomethyl)-2-(trifluoromethyl)pyrimidin-4-yloxy)cyclohexyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / acetone / 21 h

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

4: ammonium hydroxide / tetrahydrofuran; water / 16 h / 25 °C

With hydrogenchloride; ammonium hydroxide; water; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetone;