7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol

Base Information

• Chemical Name: 7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol
• CAS No.: 478490-31-2
• Molecular Formula: C₃₄H₄₉F₅O₆S₂
• Molecular Weight: 712.883
• Mol file: 478490-31-2.mol

Synonyms:7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol

Chemical Property of 7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol

There total 1 articles about 7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-bromononan-1-ol (55362-80-6) → 7α-{9-[(4,4,5,5,5-pentafluoropentyl)thio]nonyl}-3-O-methoxymethyl-16β,17β-O-sulfurylestra-1,3,5(10)-triene-3,16β,17β-triol (478490-31-2)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 95 percent / imidazole / tetrahydrofuran / 2 h / 20 °C

2.1: Mg / tetrahydrofuran / 2 h / Heating

2.2: 37 percent / CuI / tetrahydrofuran / 0.67 h

3.1: 81 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / 0 - 20 °C

4.1: aq. AcOH / tetrahydrofuran / 50 °C

5.1: 2.28 g / N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

6.1: 68 percent / CuBr₂; LiBr / acetonitrile / 0.5 h / Heating

7.1: 66 percent / H₂SO₄ / 4 h / Heating

8.1: 81 percent / Pb(OAc)4 / acetic acid / 3.5 h

9.1: Li(t-BuO)3AlH / tetrahydrofuran / 1 h

10.1: 0.64 g / aq. K₂CO₃ / methanol / 2 h / 20 °C

11.1: 91 percent / NaH / tetrahydrofuran / 1 h

12.1: 62 percent / DMAP / CH₂Cl₂ / 15 h / 0 - 20 °C

13.1: 91 percent / ethanol / 2.5 h / 50 °C

14.1: 0.36 mg / aq. NaOH / methanol / 1 h / 50 °C

15.1: NaH / tetrahydrofuran / 0.17 h

15.2: 97 percent / sulfonyldiimidazole / tetrahydrofuran / 1 h

With 1H-imidazole; lead(IV) acetate; dmap; sodium hydroxide; sulfuric acid; sodium hydride; potassium carbonate; magnesium; acetic acid; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; lithium bromide; copper(ll) bromide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; acetonitrile;

DOI:10.1039/b205571f

upstream raw materials:

9-bromononan-1-ol