2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

Base Information

Chemical Name:2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol
CAS No.:1355330-20-9
Molecular Formula:C₂₀H₂₁N₃O₆
Molecular Weight:399.403
Hs Code.:

Synonyms:2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

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Chemical Property of 2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

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Technology Process of 2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

There total 5 articles about 2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1355330-37-8
5-(4-(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]-dioxol-5-yl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

: 1355330-20-9
2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; for 5h; Reflux;
DOI:10.1016/j.bmc.2011.11.010

Reference yield:

: 1355330-35-6
4-(methoxymethoxy)-2,2-dimethylbenzo[d][1,3]-dioxole-5-carbaldehyde

: 1355330-20-9
2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane; n-heptane; ethylbenzene / 1 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: ethylmagnesium chloride / tetrahydrofuran / 0.25 h / 50 °C / Inert atmosphere

2.2: 3 h / 50 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran / 5 h / Reflux

With hydrogenchloride; water; ethylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; 1.1: Colvin rearrangement / 1.2: Colvin rearrangement;
DOI:10.1016/j.bmc.2011.11.010

Reference yield:

: 1355330-36-7
5-ethynyl-4-(methoxymethoxy)-2,2-dimethylbenzo-[d]-[1,3]dioxole

: 1355330-20-9
2,2-dimethyl-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzo[d][1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium chloride / tetrahydrofuran / 0.25 h / 50 °C / Inert atmosphere

1.2: 3 h / 50 °C / Inert atmosphere

2.1: hydrogenchloride; water / tetrahydrofuran / 5 h / Reflux

With hydrogenchloride; water; ethylmagnesium chloride; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.11.010