ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate

Base Information

• Chemical Name: ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate
• CAS No.: 1009319-50-9
• Molecular Formula: C₂₆H₃₆N₂O₇
• Molecular Weight: 488.581

Synonyms:ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate

Chemical Property of ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate

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Technology Process of ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate

There total 1 articles about ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

p(E)-B-(tri-n-butylstannyl)vinyl-N-Boc-glycylaniline (1009319-49-6) + ethyl (Z)-2-bromo-4-(tetrahydro-2H-pyran-2-yloxy)-2-butenoate (344907-78-4) → ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate (1009319-50-9)

Guidance literature:

With trifuran-2-yl-phosphane; lithium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; for 0.5h;

DOI:10.1002/anie.200702989

Reference yield: 100.0%

ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate (1009319-50-9) → ethyl (E,E)-4-hydroxy-2-[4-(2-aminoacetamido)styryl]but-2-enoate (1009319-52-1)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 2h;

DOI:10.1002/anie.200702989

Reference yield:

ethyl (E,E)-2-[4-(N-tert-butoxycarbonyl-2-aminoacetamido)styryl]-4-(tetrahydro-2H-pyran-2-yloxy)but-2-enoate (1009319-50-9) → C16H20N2O4

Guidance literature:

With hydrogenchloride; In methanol; water; at 0 - 20 ℃; for 2h;

DOI:10.1039/c3ob42267d

upstream raw materials:

p(E)-B-(tri-n-butylstannyl)vinyl-N-Boc-glycylaniline

ethyl (Z)-2-bromo-4-(tetrahydro-2H-pyran-2-yloxy)-2-butenoate

Downstream raw materials:

ethyl (E,E)-4-hydroxy-2-[4-(2-aminoacetamido)styryl]but-2-enoate

C₂₃H₂₉N₅O₅

ethyl (E,E)-4-Hydroxy-2-{4-[2-(7-azidoheptanamido)acetamido]styryl}but-2-enoate

ethyl (E,E)-4-hydroxy-2-[4-(5,6-dihydro-11,12-didehydro-dibenzo[a,e]cyclooctenyl-5-oxcarbonylaminoacetamide)styryl]but-2-enoate

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