N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Base Information

• Chemical Name: N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide
• CAS No.: 864738-87-4
• Molecular Formula: C₃₆H₄₄Br₂N₄O₇
• Molecular Weight: 804.576

Synonyms:N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Chemical Property of N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

There total 4 articles about N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-[(1,1-dimethylethoxy)carbonyl]-3,5-dibromo-D-tyrosine (349535-07-5) + N6-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide (246514-90-9) → N2-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N6-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide (864738-87-4)

Guidance literature:

N-[(1,1-dimethylethoxy)carbonyl]-3,5-dibromo-D-tyrosine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.25h;

N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide; In tetrahydrofuran; at -15 - 20 ℃;

DOI:10.1021/jm0490641

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → N2-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N6-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide (864738-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

2.1: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3.2: 79 percent / tetrahydrofuran / -15 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

Reference yield:

phenethylamine (64-04-0) → N2-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N6-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide (864738-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / diisopropylethylamine; TBTU; HOBt / dimethylformamide / 20 °C

2.1: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3.2: 79 percent / tetrahydrofuran / -15 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0490641

upstream raw materials:

N-[(1,1-dimethylethoxy)carbonyl]-3,5-dibromo-D-tyrosine

N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Boc-Lys(Z)-OH

phenethylamine

Downstream raw materials:

N²-[3,5-dibromo-N-(4-phenyl-1-oxobutyl)-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

N²-[3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 864738-87-4 N²-[N-(1,1-dimethylethoxycarbonyl)-3,5-dibromo-D-tyrosyl]-N⁶-(phenylmethoxycarbonyl)-L-lysine-2-phenethylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send