cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

Base Information

Chemical Name:cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile
CAS No.:1607590-04-4
Molecular Formula:C₁₄H₁₄N₄O₂S
Molecular Weight:302.357
Hs Code.:

Synonyms:cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

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Chemical Property of cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

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Technology Process of cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

There total 5 articles about cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607590-04-4
cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5.1: sodium cyanide / dimethyl sulfoxide / 6 h / 90 °C

With sodium cyanide; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1607590-03-3
trans-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl methanesulfonate

: 1607590-04-4
cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

Guidance literature:: With sodium cyanide; In dimethyl sulfoxide; at 90 ℃; for 6h;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607590-04-4
cis-4-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3: sodium cyanide / dimethyl sulfoxide / 6 h / 90 °C

With sodium cyanide; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;