(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

Base Information

Chemical Name:(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate
CAS No.:1159997-55-3
Molecular Formula:C₂₆H₂₃F₃N₂O₃
Molecular Weight:468.475
Hs Code.:

Synonyms:(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

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Chemical Property of (R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

Chemical Property:

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Technology Process of (R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

There total 7 articles about (R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.1%

: 1159997-92-8
(R)-(-)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 30806-83-8
p-ethoxycarbonylphenyl isocyanate

: 1159997-55-3
(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm401955h

Reference yield:

: 64-04-0
phenethylamine

: 1159997-55-3
(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: phosphorus pentoxide / 165 °C

3: sodium tetrahydroborate / methanol / 20 °C

4: chiral column / Resolution of racemate

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

With sodium tetrahydroborate; phosphorus pentoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/jm401955h

Reference yield:

: 38925-76-7
N-phenethyl-4-(trifluoromethyl)benzamide

: 1159997-55-3
(R)-ethyl-4-(1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentoxide / 165 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: chiral column / Resolution of racemate

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C

With sodium tetrahydroborate; phosphorus pentoxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; 1: |Bischler-Napieralski Reaction;
DOI:10.1021/jm401955h