2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Base Information

Chemical Name:2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol
CAS No.:1362910-93-7
Molecular Formula:C₂₂H₁₅F₃N₂OS
Molecular Weight:412.435
Hs Code.:

Synonyms:2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Suppliers and Price of 2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

There total 5 articles about 2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1362910-89-1
7-bromo-2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazoline

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1362910-93-7
2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; at 110 - 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 94010-78-3
2,2-difluoro-2-(4-fluorophenyl)acetic acid

: 1362910-93-7
2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl polyphosphate / 130 °C

2: Lawessons reagent / toluene / 100 °C

3: potassium carbonate / ethanol / 1.5 h / 20 °C

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 110 - 120 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; ethanol; water; toluene;

Reference yield:

: 112253-70-0
2-amino-4-bromobenzamide

: 1362910-93-7
2-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl polyphosphate / 130 °C

2: Lawessons reagent / toluene / 100 °C

3: potassium carbonate / ethanol / 1.5 h / 20 °C

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 110 - 120 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; ethanol; water; toluene;