3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

Base Information

Chemical Name:3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile
CAS No.:1093951-44-0
Molecular Formula:C₁₆H₁₆BrN₃O
Molecular Weight:346.227
Hs Code.:

Synonyms:3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

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Chemical Property of 3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

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Technology Process of 3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

There total 2 articles about 3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1093951-45-1
1-cyclopentyl-4-methoxy-1,5-dihydropyrrol-2-one

: 114344-60-4
2-amino-3-bromo-benzonitrile

: 1093951-44-0
3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

Guidance literature:: With methanesulfonic acid; In acetonitrile; at 20 ℃; for 4h; Heating / reflux;

Reference yield:

: 1003-03-8
Cyclopentamine

: 1093951-44-0
3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; acetonitrile / 20 °C

2: methanesulfonic acid; acetic acid / 1.25 h / 80 °C

With methanesulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2011.03.035

Reference yield:

: 1093951-44-0
3-bromo-2-(1-cyclopentyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl-amino)benzonitrile

: 1093949-83-7
9-amino-2-cyclopentyl-5-(2,5-dimethoxyphenyl)-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / tert-butyl alcohol / 3 h / 45 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol; water / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; sodium t-butanolate; In 1,2-dimethoxyethane; ethanol; water; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.03.035