3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Name:3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine
CAS No.:1401731-60-9
Molecular Formula:C₁₉H₂₃N₅
Molecular Weight:321.425
Hs Code.:

Synonyms:3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

There total 6 articles about 3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401732-56-6
1-(4-methoxybenzyl)-3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

: 1401731-60-9
3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: 1-(4-methoxybenzyl)-3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine; With trifluoroacetic acid; In chloroform; at 50 ℃; for 12h;

With water; pH=8;

Reference yield:

: 885223-65-4,916258-22-5
5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine

: 1401731-60-9
3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

1.2: 0 - 20 °C / Reflux

2.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 90 °C / Inert atmosphere

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 100 °C / Inert atmosphere; Sealed tube

4.1: trifluoroacetic acid / chloroform / 12 h / 50 °C

4.2: pH 8

With potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401731-60-9
3-methyl-5-(3-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 90 °C / Inert atmosphere

5.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 100 °C / Inert atmosphere; Sealed tube

6.1: trifluoroacetic acid / chloroform / 12 h / 50 °C

6.2: pH 8

With hydrogen bromide; potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; copper(I) bromide; In 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;