(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

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Chemical Name:(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol
CAS No.:130740-43-1
Molecular Formula:C₄₂H₇₅NO₇Si₂
Molecular Weight:762.231
Hs Code.:

(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

Synonyms:(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

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Chemical Property of (E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

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Technology Process of (E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

There total 30 articles about (E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 130740-43-1
(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-lutidine

2: 97 percent / DIBAL-H / benzene / -78 °C

3: 1. sec-BuLi / 1. THF, -20 to 25 deg C; 2. THF; also in Et₂O

4: 1. MnO₂, 2. LiAlH₄ / 1. CH₂Cl₂, 2. Et₂O

With 2,6-dimethylpyridine; manganese(IV) oxide; lithium aluminium tetrahydride; sec.-butyllithium; diisobutylaluminium hydride; In benzene;
DOI:10.1016/S0040-4039(00)97607-X

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 130740-43-1
(E)-(1R,2R,4R,5S,6R,9S,10R)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine

2: 97 percent / DIBAL-H / benzene / -78 °C

3: 1. sec-BuLi / 1. THF, -20 to 25 deg C; 2. THF; also in Et₂O

With 2,6-dimethylpyridine; sec.-butyllithium; diisobutylaluminium hydride; In benzene;
DOI:10.1016/S0040-4039(00)97607-X

Reference yield:

: 130740-39-5
(3S,5S)-5-((E)-(1S,2R,5S,6R)-7-Benzyloxy-1-methoxy-5-methoxymethoxy-2,4,6-trimethyl-hept-3-enyl)-3-methyl-dihydro-furan-2-one

: 130740-43-1
(E)-(1R,2S,4S,5R,6S,9R,10S)-9,11-Bis-(tert-butyl-dimethyl-silanyloxy)-1-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-2,6,8,10-tetramethyl-undec-7-ene-1,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / H₂O

2: 2,6-lutidine

3: H₂ / Pd(OH)2

4: 2,6-lutidine

5: 97 percent / DIBAL-H / benzene / -78 °C

6: 1. sec-BuLi / 1. THF, -20 to 25 deg C; 2. THF; also in Et₂O

7: 1. MnO₂, 2. LiAlH₄ / 1. CH₂Cl₂, 2. Et₂O

With 2,6-dimethylpyridine; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; hydrogen; sec.-butyllithium; diisobutylaluminium hydride; palladium dihydroxide; In water; benzene;
DOI:10.1016/S0040-4039(00)97607-X