S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Base Information

• Chemical Name: S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• CAS No.: 1231191-50-6
• Molecular Formula: C₂₄H₁₈F₄N₆O
• Molecular Weight: 482.44

Synonyms:S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Chemical Property of S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

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Technology Process of S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

There total 3 articles about S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.1%

4-bromo-pyridazine hydrobromide (1220039-64-4) + (4-{1-[6-fluoro-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-1H-1,2,3-triazol-4-yl}phenyl)boronic acid (1231192-59-8) → 6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 16h;

Reference yield:

6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6) → S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6) + R-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6)

Guidance literature:

Chiral Technology OJ-H 2.1 X 25 cm, 5uM; 220nra detection; In methanol; Resolution of racemate;

Reference yield:

6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6) → S-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6) + R-6-fluoro-3-[4-(4-pyridazin-4-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1231191-50-6)

Guidance literature:

Chiral Technology OJ-H 2.1 X 25 cm, 5uM; 220nra detection; In methanol; Resolution of racemate;

upstream raw materials:

4-bromo-pyridazine hydrobromide

(4-{1-[6-fluoro-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-1H-1,2,3-triazol-4-yl}phenyl)boronic acid

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