7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

Base Information

Chemical Name:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide
CAS No.:1392841-61-0
Molecular Formula:C₁₆H₁₃N₃O₃
Molecular Weight:295.298
Hs Code.:

Synonyms:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

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Chemical Property of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

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Technology Process of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

There total 5 articles about 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-22-3
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 1392841-61-0
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 16h; Sealed tube;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392841-61-0
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: ammonia / methanol / 16 h / 20 °C / Sealed tube

With pyridine; oxalyl dichloride; ammonia; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 174740-68-2
5-dimethylamino-3-ethoxycarbonyl-2-methoxycarbonyl-penta-2,4-dienoic acid methyl ester

: 1392841-61-0
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 5 h / Reflux

2.1: pyridine; lithium iodide / 1 h / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

3.2: 16 h / 20 °C

3.3: 16 h / 20 °C

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol

5.2: pH 4

6.1: ammonia / methanol / 16 h / 20 °C / Sealed tube

With pyridine; oxalyl dichloride; ammonia; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;