2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

Base Information

Chemical Name:2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile
CAS No.:1359823-43-0
Molecular Formula:C₂₂H₂₂N₄O₂S
Molecular Weight:406.508
Hs Code.:

Synonyms:2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

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Chemical Property of 2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

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Technology Process of 2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

There total 7 articles about 2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1359823-42-9
3-phenyl-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)propanenitrile

: 137049-00-4
1-methyl-1H-imidazole-4-sulfonyl chloride

: 1359823-43-0
2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 75h;

Reference yield:

: 960305-57-1
tert-butyl 7-(cyanomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1359823-43-0
2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 20 °C

2: ethanol; sodium tetrahydroborate / 72 h / 0 - 20 °C

3: formic acid / 1 h / 20 °C

4: dmap / dichloromethane / 75 h / 20 °C

With dmap; sodium tetrahydroborate; formic acid; ethanol; sodium ethanolate; In ethanol; dichloromethane;

Reference yield:

: 149353-95-7
2-[(tert-butoxy)carbonyl]-1 ,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

: 1359823-43-0
2-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-3-phenylpropanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 20 °C

2: triethylamine; phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: sodium ethanolate / ethanol / 20 °C

5: ethanol; sodium tetrahydroborate / 72 h / 0 - 20 °C

6: formic acid / 1 h / 20 °C

7: dmap / dichloromethane / 75 h / 20 °C

With dmap; sodium tetrahydroborate; formic acid; ethanol; dimethylsulfide borane complex; sodium ethanolate; phosphorus tribromide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;