1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester

Base Information

• Chemical Name: 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester
• CAS No.: 181235-21-2
• Molecular Formula: C₂₀H₂₈O₄
• Molecular Weight: 332.44
• Mol file: 181235-21-2.mol

Synonyms:1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property of 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester

There total 1 articles about 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

bromoacetic acid tert-butyl ester (5292-43-3) + benzyl cyclohexanecarboxylate (22733-94-4) → 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester (181235-21-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/0960-894X(96)00303-4

Reference yield:

1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester (181235-21-2) → 1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0960-894X(96)00303-4

Reference yield:

1-tert-Butoxycarbonylmethyl-cyclohexanecarboxylic acid benzyl ester (181235-21-2) → {1-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-cyclohexyl}-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: DEC, HOBT / CH₂Cl₂; triethylamine

3: TFA / CH₂Cl₂

With diethylcarbamazine; hydrogen; benzotriazol-1-ol; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; triethylamine;

DOI:10.1016/0960-894X(96)00303-4

upstream raw materials:

bromoacetic acid tert-butyl ester

benzyl cyclohexanecarboxylate