tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Base Information

Chemical Name:tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate
CAS No.:1429293-46-8
Molecular Formula:C₂₂H₂₉Cl₂N₃O₅
Molecular Weight:486.395
Hs Code.:

Synonyms:tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

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Chemical Property of tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

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Technology Process of tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

There total 2 articles about tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1429293-20-8
(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 1429293-46-8
tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Guidance literature:: N-(t-butoxycarbonyl)glycinal; tert-butyl 3-aminopropanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In methanol; at 60 ℃; for 0.166667h; Microwave irradiation;

(Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide; In methanol; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 39959-89-2
3-(3,4-dichlorophenyl)propan-1-amine hydrochloride

: 1429293-46-8
tert-butyl 3-(2-(aminomethyl)-3-(3-(3,4-dichlorophenyl)propyl-carbamoyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / methanol / 0.17 h / 60 °C / Microwave irradiation

2.2: 0.25 h / 100 °C / Microwave irradiation

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;