(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Base Information

Chemical Name:(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
CAS No.:1404322-08-2
Molecular Formula:C₁₉H₁₅F₂N₅O₂
Molecular Weight:383.357
Hs Code.:

Synonyms:(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

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Chemical Property of (S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Chemical Property:

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Technology Process of (S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

There total 28 articles about (S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404337-23-0
C₃₇H₃₅F₂N₅O₆

: 1404322-08-2
(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 80 ℃; for 14h;

Reference yield:

: C₁₉H₂₆F₄N₂O₅S

: 1404322-08-2
(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 11 steps

1: Dess-Martin periodane / dichloromethane / 0.67 h / 20 °C

2: water; hydrogenchloride / methanol / 1 h / 20 °C

3: potassium carbonate / ethyl acetate; water / 0.5 h / 0 °C

4: dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 27 h / 20 °C

6: acetic acid / tert-butyl alcohol / 2.5 h / 90 °C

7: sodium methylate; methanol / 1.5 h / 20 °C

8: diethylamino-sulfur trifluoride / dichloromethane / 2.58 h / 0 - 20 °C

9: water; potassium carbonate / tetrahydrofuran; methanol / 5 h / 50 °C

10: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.83 h

11: trifluoroacetic acid; methoxybenzene / 14 h / 80 °C

With hydrogenchloride; methanol; dmap; diethylamino-sulfur trifluoride; water; sodium methylate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: C₁₄H₁₆F₄N₂O₂S

: 1404322-08-2
(S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: diethyl ether; tetrahydrofuran / 0.75 h / -78 °C

2.1: 4-methylmorpholine N-oxide; potassium osmate(VI) dihydrate; water / acetone / 6.5 h / 20 °C

3.1: dmap; pyridine / dichloromethane / 0.17 h / 20 °C

3.2: 0.67 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 0.67 h / 20 °C

5.1: water; hydrogenchloride / methanol / 1 h / 20 °C

6.1: potassium carbonate / ethyl acetate; water / 0.5 h / 0 °C

7.1: dichloromethane / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 27 h / 20 °C

9.1: acetic acid / tert-butyl alcohol / 2.5 h / 90 °C

10.1: sodium methylate; methanol / 1.5 h / 20 °C

11.1: diethylamino-sulfur trifluoride / dichloromethane / 2.58 h / 0 - 20 °C

12.1: water; potassium carbonate / tetrahydrofuran; methanol / 5 h / 50 °C

13.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.83 h

14.1: trifluoroacetic acid; methoxybenzene / 14 h / 80 °C

With pyridine; hydrogenchloride; methanol; dmap; potassium osmate(VI) dihydrate; diethylamino-sulfur trifluoride; water; sodium methylate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; methoxybenzene; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;