Technology Process of (9aR*,9bS*)-5a-Aza-2,5,6,7,8,9,9a,9b-octahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene
There total 7 articles about (9aR*,9bS*)-5a-Aza-2,5,6,7,8,9,9a,9b-octahydro-5-oxo-4-oxa-3-phenyl-1H-benzazulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tin(IV) chloride;
In
dichloromethane;
at -23 ℃;
for 0.0833333h;
DOI:10.1021/jo00292a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine / CHCl3 / 12 h / Ambient temperature
2: NaI / acetone / 2 h / Heating
3: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature
4: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature
5: 1) Li(Et)3BH 2) HCl / 1) THF, -78 deg C 2) -78 deg C -> room temperature
6: 80 percent / SnCl4 / CH2Cl2 / 0.08 h / -23 °C
With
pyridine; hydrogenchloride; tin(IV) chloride; lithium triethylborohydride; sodium iodide; lithium diisopropyl amide;
In
dichloromethane; chloroform; acetone;
DOI:10.1021/jo00292a014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaI / acetone / 2 h / Heating
2: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature
3: 1) LDA / 1) THF, hexane, -78 deg C 2) -78 deg C -> room temperature
4: 1) Li(Et)3BH 2) HCl / 1) THF, -78 deg C 2) -78 deg C -> room temperature
5: 80 percent / SnCl4 / CH2Cl2 / 0.08 h / -23 °C
With
hydrogenchloride; tin(IV) chloride; lithium triethylborohydride; sodium iodide; lithium diisopropyl amide;
In
dichloromethane; acetone;
DOI:10.1021/jo00292a014
