(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Base Information

Chemical Name:(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
CAS No.:1430202-69-9
Molecular Formula:C₁₂H₁₄ClNO₂*ClH
Molecular Weight:276.163
Hs Code.:

Synonyms:(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Suppliers and Price of (2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
(2R,6R)-Hydroxynorketamine hydrochloride ≥98%(HPLC)
10
$ 298.00

Sigma-Aldrich
(2R,6R)-Hydroxynorketamine hydrochloride ≥98% (HPLC)
5 mg
$ 110.00

Sigma-Aldrich
(2R,6R)-Hydroxynorketamine hydrochloride ≥98% (HPLC)
25 mg
$ 443.00

Cayman Chemical
(2R,6R)-Hydroxynorketamine (hydrochloride)
5mg
$ 333.00

Cayman Chemical
(2R,6R)-Hydroxynorketamine (hydrochloride)
1mg
$ 95.00

AK Scientific
(2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one;hydrochloride
5mg
$ 549.00

Total 25 raw suppliers

Chemical Property of (2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R,6R)-Hydroxynorketamine hydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

There total 11 articles about (2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: tert-butyl ((1R,3R)-1-(2-chlorophenyl)-3-hydroxy-2-oxocyclohexyl)carbamate

: 1430202-69-9
(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Guidance literature:: tert-butyl ((1R,3R)-1-(2-chlorophenyl)-3-hydroxy-2-oxocyclohexyl)carbamate; With trifluoroacetic acid; In dichloromethane;

With hydrogenchloride; In ethyl acetate;
DOI:10.1021/acs.orglett.7b02177

Reference yield:

: C₂₀H₃₀ClNO₃Si

: 1430202-69-9
(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -15 - 20 °C

1.2: 0 °C

2.1: trifluoroacetic acid / dichloromethane

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/acs.orglett.7b02177

Reference yield:

: R-norketamine (L)-pyroglutamate

: 1430202-69-9
(2R,6R)-(+)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethyl acetate; water

2.1: potassium carbonate / toluene / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3.2: -78 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -15 - 20 °C

4.2: 0 °C

5.1: trifluoroacetic acid / dichloromethane

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/acs.orglett.7b02177