2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:185961-30-2
Molecular Formula:C₄₅H₅₀F₂N₈O₅
Molecular Weight:820.939
Hs Code.:

2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Synonyms:2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

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Technology Process of 2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

There total 5 articles about 2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171228-61-8
(2S,3R)-2-Benzyloxymethoxy-pentan-3-ol

: 185961-30-2
2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP

2: Cs₂CO₃ / dimethylformamide / Heating

With dmap; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.031

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 185961-30-2
2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: DIBAL-H

2: diethyl ether / -78 - 20 °C

3: DMAP

4: Cs₂CO₃ / dimethylformamide / Heating

With dmap; diisobutylaluminium hydride; caesium carbonate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.031

Reference yield:

: 63296-56-0
(S)-(benzyloxymethoxy)propanal

: 185961-30-2
2-((1S,2S)-2-Benzyloxymethoxy-1-ethyl-propyl)-4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / -78 - 20 °C

2: DMAP

3: Cs₂CO₃ / dimethylformamide / Heating

With dmap; caesium carbonate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.031