2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE
• CAS No.: 91396-13-3
• Molecular Formula: C12H12 Cl N3
• Molecular Weight: 233.7
• Mol file: 91396-13-3.mol

Synonyms:Pyrimidine,4-(benzylamino)-2-chloro-5-methyl- (7CI);N-Benzyl-2-chloro-5-methyl-4-pyrimidinamine

Chemical Property of 2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 3.56E-07mmHg at 25°C
• Refractive Index: 1.638
• Boiling Point: 417.4°Cat760mmHg
• Flash Point: 206.2°C
• PSA: 37.81000
• Density: 1.268g/cm³
• LogP: 3.12350

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE

There total 3 articles about 2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + benzylamine (100-46-9) → N-benzyl-2-chloro-5-methylpyrimidin-4-amine (91396-13-3)

Guidance literature:

With triethylamine; In butan-1-ol; at 110 ℃; for 2h;

Reference yield: 72.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + benzylamine (100-46-9) → 2-(benzylamino)-5-methylpyrimidin-4-ol (57465-67-5) + N-benzyl-2-chloro-5-methylpyrimidin-4-amine (91396-13-3)

Guidance literature:

With ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate; In water; at 50 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.083

Reference yield:

→ N-benzyl-2-chloro-5-methylpyrimidin-4-amine (91396-13-3)

Guidance literature:

2,4-Dichlor-5-methylpyrimidin, Benzylamin/BuOH/Wasser (15 min Wasserbad);

upstream raw materials:

2,6-dichloro-5-methylpyrimidine

benzylamine

Refernces

• 1、 -. "MULTI-SUBSTITUTED PYRIMIDINE DERIVATIVES WITH EXCELLENT KINASE INHIBITORY ACTIVITIES". Paragraph 0187; 0188. . Retrieved 2019/10/29.