(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

Base Information

Chemical Name:(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one
CAS No.:176774-60-0
Molecular Formula:C₁₆H₂₈O₃
Molecular Weight:268.397
Hs Code.:

Synonyms:(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

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Chemical Property of (3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

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Technology Process of (3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

There total 4 articles about (3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-Eth-(E)-ylidene-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

: 176774-60-0
(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; for 5h; under 2585.7 Torr; Yield given; Ambient temperature;
DOI:10.1016/0040-4039(96)00310-3

Reference yield:

: 122079-41-8
(5S)-(D-menthyloxy)-2(5H)-furanone

: 176774-60-0
(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, Et₃N / 10percent Pd/C / ethyl acetate / 16 h / 2585.7 Torr / Ambient temperature

2: LDA / tetrahydrofuran / 1 h / -78 °C

3: methanesulfonyl chloride, triethylamine / 1,2-dichloro-ethane / 0 deg C, 30 min; RT, 2 h; reflux, 5 h

4: H₂, triethylamine / 10percent Pd/C / ethanol / 5 h / 2585.7 Torr / Ambient temperature

With hydrogen; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(96)00310-3

Reference yield:

: (S)-3-(1-Hydroxy-ethyl)-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

: 176774-60-0
(3S,5S)-3-Ethyl-5-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride, triethylamine / 1,2-dichloro-ethane / 0 deg C, 30 min; RT, 2 h; reflux, 5 h

2: H₂, triethylamine / 10percent Pd/C / ethanol / 5 h / 2585.7 Torr / Ambient temperature

With hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(96)00310-3